Antidiabetic activity and mechanisms of acarbose in KKAy mice
The Korean Journal of Physiology and Pharmacology
;
: 183-188, 2001.
Artículo
en Inglés
| WPRIM
| ID: wpr-728219
ABSTRACT
To elucidate antidiabetic effect and mechanism(s) of acarbose in a polygenic spontaneous hyperglycemic and hyperinsulinemic diabetic animal model, KKAy mice, acarbose was administered orally for 4 weeks and effects on body weight, plasma glucose and insulin levels, genetic expressions of intestinal sucrase-isomaltase (SI), sodium-glucose cotransporter (sGLT1) and glucose transporter in quadriceps muscle (GLUT4) were examined in this study. Although no differences in body weight were detected between control and acarbose-treated groups, plasma glucose level in acarbose-treated group was markedly reduced as compared to the control. In the mechanism study, acarbose downregulated the SI and SGLT1 gene expressions, and upregulated the GLUT4 mRNA and protein expressions when compared to the control group. In conclusion, the data obtained strongly implicate that acarbose can prevent the hyperglycemia in KKAy mice possibly through blocking intestinal glucose absorption by downregulations of SI and sGLT1 mRNA expressions, and upregulation of skeletal muscle GLUT4 mRNA and protein expressions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glucemia
/
Peso Corporal
/
ARN Mensajero
/
Expresión Génica
/
Regulación hacia Arriba
/
Músculo Esquelético
/
Acarbosa
/
Modelos Animales
/
Absorción
/
Músculo Cuádriceps
Límite:
Animales
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2001
Tipo del documento:
Artículo
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