Pre-ischemic Treatment with Ampicillin Reduces Neuronal Damage in the Mouse Hippocampus and Neostriatum after Transient Forebrain Ischemia
The Korean Journal of Physiology and Pharmacology
;
: 287-291, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-728374
ABSTRACT
Ampicillin, a beta-lactam antibiotic, has been reported to induce astrocytic glutamate transporter-1 which plays a crucial role in protecting neurons against glutamate excitotoxicity. We investigated the effect of ampicillin on neuronal damage in the mouse hippocampus and neostriatum following transient global forebrain ischemia. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral occlusion of the common carotid artery for 40 min. Ampicillin was administered post-ischemically (for 3 days) and/or pre-ischemically (for 3~5 days until one day before the onset of ischemia). Pre- and post-ischemic treatment with ampicillin (50 mg/kg/day or 200 mg/kg/day) prevented ischemic neuronal death in the medial CA1 area of the hippocampus as well as the neostriatum in a dose-dependent manner. In addition, ischemic neuronal damage was reduced by pre-ischemic treatment with ampicillin (200 mg/kg/day). In summary, our results suggest that ampicillin plays a functional role as a chemical preconditioning agent that protects hippocampal neurons from ischemic insult.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Prosencéfalo
/
Neostriado
/
Arteria Carótida Común
/
Ácido Glutámico
/
Halotano
/
Hipocampo
/
Ampicilina
/
Isquemia
/
Neuronas
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2008
Tipo del documento:
Artículo
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