Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts
The Korean Journal of Physiology and Pharmacology
; : 269-277, 2016.
Article
en En
| WPRIM
| ID: wpr-728446
Biblioteca responsable:
WPRO
ABSTRACT
Ellagic acid (EA), an antioxidant polyphenolic constituent of plant origin, has been reported to possess diverse pharmacological properties, including anti-inflammatory, anti-tumor and immunomodulatory activities. This work aimed to clarify the skin anti-photoaging properties of EA in human dermal fibroblasts. The skin anti-photoaging activity was evaluated by analyzing the reactive oxygen species (ROS), matrix metalloproteinase-2 (MMP-2), total glutathione (GSH) and superoxide dismutase (SOD) activity levels as well as cell viability in dermal fibroblasts under UV-B irradiation. When fibroblasts were exposed to EA prior to UV-B irradiation, EA suppressed UV-B-induced ROS and proMMP-2 elevation. However, EA restored total GSH and SOD activity levels diminished in fibroblasts under UV-B irradiation. EA had an up-regulating activity on the UV-B-reduced Nrf2 levels in fibroblasts. EA, at the concentrations used, was unable to interfere with cell viabilities in both non-irradiated and irradiated fibroblasts. In human dermal fibroblasts, EA plays a defensive role against UV-B-induced oxidative stress possibly through an Nrf2-dependent pathway, indicating that this compound has potential skin antiphotoaging properties.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Plantas
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Piel
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Superóxido Dismutasa
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Supervivencia Celular
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Especies Reactivas de Oxígeno
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Estrés Oxidativo
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Metaloproteinasa 2 de la Matriz
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Ácido Elágico
/
Fibroblastos
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Glutatión
Límite:
Humans
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2016
Tipo del documento:
Article