Fucoidan Promotes the Reconstruction of Skin Equivalents
The Korean Journal of Physiology and Pharmacology
;
: 327-331, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-728461
ABSTRACT
In this study we investigated the effects of fucoidan on the proliferation of fibroblasts and the reconstruction of a skin equivalent (SE). Fucoidan significantly stimulated the proliferation of CCD-25Sk human fibroblasts and Western blot analysis demonstrated that fucoidan markedly increased the expression of cyclin D1 and decreased the expression of p27. Fucoidan was used to reconstruct SE. Immunohistochemical staining showed that the addition of fucoidan to dermal equivalents increased expression of proliferating cell nuclear antigen (PCNA) and p63. In addition, expression of alpha6-integrin was significantly increased by fucoidan, whereas expression of beta1-integrin, type 1 collagen, elastin, fibronectin did not markedly change. These results suggest that fucoidan has positive effects on epidermal reconstruction and will therefore be beneficial in the reconstruction of SE.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Western Blotting
/
Elastina
/
Fibronectinas
/
Antígeno Nuclear de Célula en Proliferación
/
Ciclina D1
/
Colágeno Tipo I
/
Fibroblastos
Límite:
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2014
Tipo del documento:
Artículo
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