Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
The Korean Journal of Physiology and Pharmacology
;
: 113-119, 2007.
Artículo
en Inglés
| WPRIM
| ID: wpr-728479
ABSTRACT
Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Serotonina
/
Discapacidades del Desarrollo
/
Ratas Sprague-Dawley
/
Pruebas de Mesa Inclinada
/
Modelos Animales
/
Receptor de Serotonina 5-HT1A
/
Inflamación
/
Manifestaciones Neurológicas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2007
Tipo del documento:
Artículo
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