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The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells
The Korean Journal of Physiology and Pharmacology ; : 267-273, 2017.
Artículo en Inglés | WPRIM | ID: wpr-728571
ABSTRACT
The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colonderived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer. PIG3 overexpression increases the colony formation, migration and invasion ability of HCT116 colon cancer cells. Conversely, these tumorigenic abilities were significantly decreased in in vitro studies with PIG3 knockdown HCT116 cells. PIG3 knockdown also attenuated the growth of mouse xenograft tumors. These results demonstrate that PIG3 is associated with the tumorigenic potential of cancer cells, both in vitro and in vivo, and could play a key oncogenic role in colon cancer.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Técnicas In Vitro / Línea Celular / Genes vif / Especies Reactivas de Oxígeno / Colon / Neoplasias del Colon / Células HCT116 / Fibroblastos / Xenoinjertos / Carcinogénesis Límite: Animales / Humanos Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Técnicas In Vitro / Línea Celular / Genes vif / Especies Reactivas de Oxígeno / Colon / Neoplasias del Colon / Células HCT116 / Fibroblastos / Xenoinjertos / Carcinogénesis Límite: Animales / Humanos Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo