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Quercetin induces apoptosis and cell cycle arrest in triple-negative breast cancer cells through modulation of Foxo3a activity
The Korean Journal of Physiology and Pharmacology ; : 205-213, 2017.
Artículo en Inglés | WPRIM | ID: wpr-728578
ABSTRACT
Quercetin, a plant-derived flavonoid found in fruits, vegetables and tea, has been known to possess bioactive properties such as anti-oxidant, anti-inflammatory and anti-cancer. In this study, anti-cancer effect of quercetin and its underlying mechanisms in triple-negative breast cancer cells was investigated. MTT assay showed that quercetin reduced breast cancer cell viability in a time and dose dependent manner. For this, quercetin not only increased cell apoptosis but also inhibited cell cycle progression. Moreover, quercetin increased FasL mRNA expression and p51, p21 and GADD45 signaling activities. We also observed that quercetin induced protein level, transcriptional activity and nuclear translocation of Foxo3a. Knockdown of Foxo3a caused significant reduction in the effect of quercetin on cell apoptosis and cell cycle arrest. In addition, treatment of JNK inhibitor (SP 600125) abolished quercetin-stimulated Foxo3a activity, suggesting JNK as a possible upstream signaling in regulation of Foxo3a activity. Knockdown of Foxo3a and inhibition of JNK activity reduced the signaling activities of p53, p21 and GADD45, triggered by quercetin. Taken together, our study suggests that quercetin induces apoptosis and cell cycle arrest via modification of Foxo3a signaling in triple-negative breast cancer cells.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Quercetina / Té / Verduras / Neoplasias de la Mama / ARN Mensajero / Ciclo Celular / Supervivencia Celular / Apoptosis / Puntos de Control del Ciclo Celular / Neoplasias de la Mama Triple Negativas Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Quercetina / Té / Verduras / Neoplasias de la Mama / ARN Mensajero / Ciclo Celular / Supervivencia Celular / Apoptosis / Puntos de Control del Ciclo Celular / Neoplasias de la Mama Triple Negativas Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2017 Tipo del documento: Artículo