Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10
The Korean Journal of Physiology and Pharmacology
;
: 79-81, 2008.
Artículo
en Inglés
| WPRIM
| ID: wpr-728604
ABSTRACT
The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN-induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-alpha, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Benzopiranos
/
Butiratos
/
Punciones
/
Interleucina-6
/
Factor de Necrosis Tumoral alfa
/
Interleucina-10
/
Sepsis
/
Interleucina-12
/
Ligadura
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
The Korean Journal of Physiology and Pharmacology
Año:
2008
Tipo del documento:
Artículo
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