Effect of Korean Red Ginseng on Testicular Tissue Injury after Torsion and Detorsion
Korean Journal of Urology
;
: 794-799, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-7287
ABSTRACT
PURPOSE:
Korean red ginseng (KRG) is a potent antioxidant and a free radical scavenger. This study was designed to determine whether KRG could protect against dysfunction and oxidative stress induced by torsion-detorsion injury in rat testis. MATERIALS ANDMETHODS:
Six-week-old male Sprague-Dawley rats were randomly divided into four groups a sham-operated control group (C), a sham-operated and KRG-treated group (K), a 2 hours torsion and detorsion group (T), and a 2 hours torsion and detorsion and KRG-treated group (T+K). We measured testis weight and hormone levels and reactive oxygen species (ROS) from the left renal vein. Superoxide generation was measured on the basis of lucigenin-enhanced chemiluminescence in testis tissue.RESULTS:
Testicular weight was significantly higher in the T+K group than in the T group; however, there were no significant differences in hormone levels between the 4 groups. The mean level of ROS and superoxide production was significantly higher in the T group than in the C group, whereas administration of KRG attenuated this increase. Upon histologic evaluation, the T group was found to have cellular disarray, a lack of cellular cohesiveness, degenerative changes in the germinal cells, and less distinct changes in the seminiferous tubules, whereas the T+K group had a germinal epithelial layer that appeared nearly normal.CONCLUSIONS:
The present study demonstrated that KRG recovered the testis dysfunction in the rat testis by suppressing superoxide production.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Venas Renales
/
Túbulos Seminíferos
/
Torsión del Cordón Espermático
/
Testículo
/
Especies Reactivas de Oxígeno
/
Ratas Sprague-Dawley
/
Superóxidos
/
Estrés Oxidativo
/
Luminiscencia
/
Panax
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Korean Journal of Urology
Año:
2010
Tipo del documento:
Artículo
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