The Fasting Serum Glucose, Insulin and C-peptide Levels in Children with Obesity / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 73-80, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-72987
ABSTRACT
PURPOSE:
The prevalence of childhood obesity has been increased rapidly, associated with high morbidity of dyslipidemia, cardiovascular risk factors and insulin resistance/hyperinsulinemia. Hyperinsulinemia in obese children may depend on either increased insulin secretion or decreased insulin clearance. We investigate whether insulin secretion and clearance are different between obese and normal weight children.METHODS:
The body mass index(BMI), fasting serum glucose, insulin and C-peptide levels were measured in 101 children(52 obese children and 49 non-obese controls) in Ansan area, from 6 to 14 years old. Fasting serum C-peptide/insulin ratio, insulin/glucose ratio, homeostasis model assessment(HOMA) were calculated and compared between obese and control group.RESULTS:
The fasting serum insulin and C-peptide levels were significantly higher in obese group than in controls. The C-peptide/insulin ratio was significantly lower and insulin/glucose ratio was significantly higher in obese group than in controls. There were positive correlations between BMI and fasting serum insulin level, fasting insulin/glucose ratio and HOMA. The prevalence of hyperinsulinemia is higher in obese adolescents than in controls.CONCLUSION:
Our findings suggest that increased insulin secretion and decreased insulin clearance may contribute to hyperinsulinemia in obese children.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glucemia
/
Péptido C
/
Prevalencia
/
Factores de Riesgo
/
Ayuno
/
Dislipidemias
/
Obesidad Infantil
/
Homeostasis
/
Hiperinsulinismo
/
Insulina
Tipo de estudio:
Estudio de etiología
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Society of Pediatric Endocrinology
Año:
2003
Tipo del documento:
Artículo
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