Gene Expression Analysis of Galpha13-/- Knockout Mouse Embryos Reveals Perturbations in Galpha13 Signaling Related to Angiogenesis and Hypoxia
Genomics & Informatics
;
: 161-172, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-73133
ABSTRACT
Angiogenesis is regulated by a large number of molecules and complex signaling mechanisms. The G protein Galpha13 is a part of this signaling mechanism as an endothelial cell movement regulator. Gene expression analysis of Galpha13 knockout mouse embryos was carried out to identify the role of Galpha13 in angiogenesis signaling during embryonic development. Hypoxia-inducible response factors including those acting as regulators of angiogenesis were over expressed, while genes related to the cell cycle, DNA replication, protein modification and cell-cell dissociation were under expressed. Functional annotation and network analysis indicate that Galpha13 -/- embryonic mice were exposed to hypoxic conditions. The present analysis of the time course highlighted the significantly high levels of disorder in the development of the cardiovascular system. The data suggested that hypoxia-inducible factors including those associated with angiogenesis and abnormalities related to endothelial cell division contributed to the developmental failure of Galpha13 knockout mouse embryos.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sistema Cardiovascular
/
Expresión Génica
/
Ciclo Celular
/
Ratones Noqueados
/
Proteínas de Unión al GTP
/
Células Endoteliales
/
Desarrollo Embrionario
/
Trastornos Disociativos
/
Replicación del ADN
/
Estructuras Embrionarias
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
Genomics & Informatics
Año:
2011
Tipo del documento:
Artículo
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