SAHA, TRAIL and Apoptosis in Breast Cancer / 沈阳医学院学报

ABSTRACT

Breast cancer is becoming as the most common malignant tumor that affects women?s health in the world. Numerous stud?ies have shown that histone deacetylase inhibitor SAHA and tumor necrosis factor?related apoptosis?inducing ligand ( TRAIL) can in?duce apoptosis in breast cancer cells, and the combination of TRAIL and SAHA has a synergistic effect, it can significantly enhance the breast cancer cells sensitivity to TRAIL treatment, so the strategy of SAHA and TRAIL treatment on breast cancer has become a welcome and promising method of clinical therapy.