Risk factors of developing infantile food allergy in low birth weight infants / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the risk factors of low birth weight infants with food allergy.Methods Forty-nine food allergy children who had been admitted to the neonatal intensive care unit(NICU) of Peking University Third Hospital from Jan.1,2007 to Dec.31,2011 and followed up in the Pediatrics Allergy Clinic after discharged from hospital were involved as food allergy group.Forty-nine children who had been admitted to the NICU of Peking University Third Hospital at the same time and followed up in the Child Health Care Clinic after discharged from hospital but had no manifestations of food allergy were selected by stratified sampling as control group.A questionnaire was designed to record the children's gender,gestation age,mode of delivery,feeding patterns after discharging from hospital,tobacco and alcohol consumption of their parents,allergy history of their parents,the intake of egg of the mother during lactation and the children's introduction of egg.At the same time,their hospital notes were investigated.The diseases they had and the application of parental nutrition,pulmonary surfactant and ventilator were all analyzed.Quantitative data were analyzed with Chi-square,qualitative data were analyzed with t-test.The risk factors of food allergy of the low birth weight infants were examined by unconditional Logistic regression.Results The birth weight,gender,mode of delivery,feeding patterns after discharging from hospital,parents,exposure to tobacco smoke and alcohol,the intake of egg of the mother during lactation and the children's introduction of egg between the 2 groups were no significantly different.The diseases they got and the application of parental nutrition,pulmonary surfactant and ventilator when they in hospital were no significantly different,too.The gestation age,parental history of allergy between the 2 groups were significantly different.The proportion of children of 33-35 weeks and 36-37 weeks gestation age in food allergy group were significantly higher than those in control group,while the 29-32 weeks gestation age were significantly lower than those in control group (x2 =10.312,P =0.016 ;x2 =20.753,P =0.000).But by unconditional Logistic regression analysis,only the one or both parents,history of allergy was the risk factor for the development of food allergy of the low birth weight infants(OR =5.574,P =0.004;OR =14.487,P =0.000).Conclusion Parents history of allergy is related to the development of food allergy of the low birth weight infants.