Analysis on risk factors for type 1 diabetic peripheral neuropathy in children / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the risk factors for type 1 diabetic peripheral neuropathy(DPN) in children,in order to provide a basis for its prevention.Methods The clinical data of 119 patients with type 1 diabetes in Tianjin Children's Hospital,including sex,age,course of diabetes,body mass index(BMI),blood pressure (Bp),plasma glucose,glycosylated hemoglobin,blood gasses,plasma lipid and islet β cell function were reviewed and analyzed.The patients were divided into 2 groups according to the neuro-electrophysiology features:DPN group (68 cases) and nonDPN group(51 cases).The risk factors in statistical significance were subjected to multiple Logistic regression analysis to screen for the risk factors for DPN.Results The inspection analysis,including the course of disease,BMI,plasma glucose,glycosylated hemoglobin,rate of ketoacidosis,plasma lipid and C-peptide,showed obvious differences (all P ＜0.01,0.05) between 2 groups of patients.There was no significant difference in sex,age,Bp,and plasma insulin between 2 groups of patients(all P ＞ 0.05).Multiple Logistic regression analysis revealed that the occurrence of DPN was correlated with the course of DPN (Estimate =0.73,Se =0.29,Wald =6.29,OR =2.07,95 ％ CI:1.17-3.66,P =0.01),plasma glucose (Estimate =0.86,Se =0.42,Wald =4.15,OR =2.37,95 ％ CI:1.03-5.44,P =0.04) and Cpeptide(Estimate =1.74,Se =0.44,Wald =15.93,OR =5.69,95％ CI:2.42-13.37,P =0.01).Conclusions There are many factors that may affect DPN.The course of disease,plasma glucose and C-peptide are major risk factors for DPN.Effective blood glucose control can effectively prevent the occurrence of DPN.