New progress in genetic mechanisms of congenital neutropenia / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
;
(24): 1665-1668, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-733202
ABSTRACT
Congenital neutropenia (CN) is a heterogeneous group of disorders in the inherited bone marrow failure syndromes (IBMFS),characterized by a severe decrease in the number of blood neutrophils,and a maturation arrest of bone marrow progenitor cells mainly at the promyelocyte/myeloid stage,and most of congenital neutropenia patients are susceptibility to bacterial infections in clinically.In recent years,the mutations in ELANE,GFI1,HAX1,G6PC3,WAS,CSF3R and so on are associated with the occurrence and development of CN,and with the further research,more new virulence gene will be found gradually.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Applied Clinical Pediatrics
Año:
2013
Tipo del documento:
Artículo
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