Advances in biological treatment for systemic lupus erythematosus / 中华实用儿科临床杂志

ABSTRACT

Systemic lupus erythematosus (SLE) is a common autoimmune disease with complex pathogenesis and significant clinical heterogeneity.The conventional therapies for SLE are effective in reducing clinical symptom and mortality,but some refractory patients are still nonreactive to current treatments.Recent advances in understanding of the molecular and cellular immunology of SLE pathogenesis have led to the development of novel biological treatments targeting on the different dysregulated immunological pathways involved in SLE pathogenesis.This review presents the current and the near-future novel biological immune targeted treatments,such as B cell-targeted therapy,T cell-B cell interaction blockade,cytokine blockade and immune tolerance agent.