Assessment and management of 46,XY disorders of sexual development / 中华实用儿科临床杂志

ABSTRACT

Micropenis is one of clinical manifestations of 46,XY disorders of sex development.Due to the complex etiology,the limitation of diagnostic methods,it is difficult to define the causes in some complicated cases.The abnormality in any part of the hypothalamic pituitary gonadal axis,androgen synthesis and function will influence the development of penis.Based on the statistical data of penis in comparison,trying to find the reference data for clinical application,used in the diagnosis of micropenis.For the patient raise a boy,the treatment including medicine and operation to improve the size of penis.Exogenous androgen and human chorionic gonadotrophin (HCG) treatment are the main methods in present,it can effectively promote the micropenis to increase in size.But it is debatable when to start the treatment,dosage and the duration.The potential side effects are unknown.Operation treatment can improve the hypospadias induced abnormal appearance and reconstruction of urethra.Treatment of gonadotropin can be applied to the patients who want to acquire fertility.For patients reared as female,male gonads must be removed,and estrogen replacement administered after adolescent.