The level of exhaled nitric oxide and its clinical significance in children with Mycoplasma pneumoniae pneumonia / 中国基层医药

ABSTRACT

Objective To investigate the changes of levels of exhaled nitric oxide and the clinical signifi -cance in children with Mycoplasma pneumoniae pneumonia ( MPP).Methods From June 2014 to March 2017,95 children with MPP and 64 children with bronchial pneumonia in Jinshan Branch of The Sixth People ＇s Hospital of Shanghai were collected,32 healthy children were enrolled as controls.According to the imaging examination,patients with MPP were further grouped into lobar pneumonia group,bronchopneumonia group and interstitial pneumonia group.FeNO and lung function were measured in all children.Results The level of FeNO in the MPP group was (7.25 ±3.41) ppb,which was lower than that in the non -MPP group and control group [(11.24 ±3.52) ppb,(10.51 ±4.23)ppb](t＝5.82,5.77,all P＜0.01).The level of FeNO between the non -MPP group and control group had no statistically significant difference (P＞0.05).The FEV1,FEV1/FVC%,FEF25%-75% of the MPP group[(66.23 ±13.21),(84.62 ±6.73),(58.65.±19.43)]were lower than those of the control group and non -MPP group[(91.81 ±11.36),(93.80 ±8.91),(86.80 ±20.71);(85.43 ±10.32),(90.18 ±11.35),(74.73 ± 17.91)](t＝4.35,3.62,4.78;4.56,7.12,5.06,all P＜0.01).The FEV1,FEV1/FVC%,FEF25%-75% of the non-MPP group[(85.43 ±10.32),(90.18 ±11.35),(74.73 ±17.91)]were lower than those of the control group [(91.81 ±11.36),(93.80 ±8.91),(86.80 ±20.71)] ( t＝2.12,3.05,2.53,all P＜0.05).The level of FeNO among the lobar pneumonia group,bronchopneumonia group and interstitial pneumonia group had no statistically significant difference ( all P ＞0.05 ).In the MPP group,the FEV1,FEV1/FVC%,FEF25% -75% were not associated with FeNO level(r＝-0.15,P＞0.05;r＝-0.06,P＞0.05;r＝0.07,P＞0.05).Conclusion The level of FeNO in children with MPP is lower,and the level of FeNO is not significantly correlated with the parameters of lung function,and FeNO can be used as an inflammatory marker to evaluate the correlation between MP infection and airway inflammation.