Regulation of pulpal microcirculation by calcitonin gene-related peptide / 대한치과보존학회지
Journal of Korean Academy of Conservative Dentistry
;
: 470-476, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-73404
ABSTRACT
The purpose of this study was to investigate the function of calcitonin gene-related peptide (CGRP) in regulatory mechanism of pulpal microcirculation with the aim of elucidating neurogenic inflammation. Experiments were performed on twelve cats under general anesthesia. CGRP was administered through the femoral vein to see the systemic influence and through the external carotid artery to see the local effect. Sympathetic nerve to the dental pulp was stimulated electrically and pulpal blood flow (PBF) was measured with a laser Doppler flowmeter on the canine teeth to the drug administration. The paired variables of control and experimental data were compared by paired t-test and differences with p < 0.05 were considered statistically significant. Systemic administration of CGRP (0.3 microg/kg) exerted decreases in systemic blood pressure and caused changes in PBF with an initial increase followed by decrease and a more marked second increase and decrease. Close intra-arterial (i.a.) injection of CGRP (0.03 microg/kg) resulted in slight PBF increase. The effect of CGRP resulted in no significant increase in PBF in the presence of CGRP8-37. The electrical stimulation of the sympathetic nerve alone resulted in PBF decreases. The i.a. administration of CGRP following the electrical stimulation of the sympathetic nerve compensated the decreased PBF. Therefore, CGRP effectively blocked the sympathetic nerve stimulation-induced PBF decrease. Results of the present study have provided evidences that even though the local vasodilatory function of CGRP are weak, CGRP is effectively involved in blocking the vasoconstriction caused by sympathetic nerve stimulation in the feline dental pulp.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vasoconstricción
/
Presión Sanguínea
/
Calcitonina
/
Arteria Carótida Externa
/
Péptido Relacionado con Gen de Calcitonina
/
Inflamación Neurogénica
/
Diente Canino
/
Pulpa Dental
/
Flujómetros
/
Estimulación Eléctrica
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Korean Academy of Conservative Dentistry
Año:
2005
Tipo del documento:
Artículo
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