ApoE genotyping and its clinical significance / 中华检验医学杂志

ABSTRACT

Apolipoprotein E has a dominant function in the metabolic process of triglyceride and cholesterol in multiple tissues of human .The allele of ApoE has three variants ε2,ε3,ε4 and six genotypesε2/ε2, ε3/ε3, ε4/ε4, ε2/ε3, ε2/ε4, ε3/ε4, due to polymorphisms of two common SNPs . These genotypes associated with kinds of diseases ,such as hyperlipidemia , ASCVD, and AD.In addition, they are also related to the treatment effect of statins .Thus, the detection of the ApoE genotypes is valuable and meaningful in the clinic.In this article, there is a simple discussion about the methodology of the ApoE genotypes, from the protein electrophoresis phenotyping to the rapid , precise and convenient genotyping methods, and its clinical significances.