Exposure to bisphenol A during maternal pregnancy and the emotional and behavioral impact on their preschool children / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 188-193, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-736463
ABSTRACT
Objective To explore the long-term effects of maternal pregnancy bisphenol A (BPA) exposure on emotional and behavioral problems appeared in their preschool children.Methods The study sample was a subset of the China-Anhui Birth Cohort Study (C-ABCS).A unified questionnaire was used to collect basic information on both pregnant women and their children.Free BPA concentration in maternal serum was determined by high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS).The parent-report version of the Strengths and Difficulties Questionnaire (SDQ) was used to estimate the emotional and behavioral problems in preschool children.A total of 1 713 pairs of mothers and children were included in this study.Association between BPA exposure during pregnancy and the emotional and behavioral problems in preschool children was evaluated with multinomial logistic regression model.Results Prevalence rates in 1 713 preschool children appeared as6.48% of emotional problems,8.11% for conduct problems,8.35% for hyperactivity/ inattention,2.86% for peer problems,11.38% for prosocial behaviors and 7.94% for total difficulties.Subjects were divided according to the degrees of exposure and the results showed aslow exposure group (≤0.120 ng/ml),medium exposure group (0.120<BPA<0.400 ng/ ml) and high exposure group (≥0.400 ng/ml) according to the serum BPA concentration in tertile.Results from the multivariate logistic regression analysis showed that high level of maternal BPA exposure appeared a risk factor on children's abnormal conducts (OR=1.876,95%CI1.161-3.029),more obvious in boys (OR=2.291,95%CI1.126-4.661).Conclusion Maternal exposure to high level of BPA during pregnancy might increase the detrimental effects of abnormal conducts in their preschool children,more obviously seen in boys.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Idioma:
Chino
Revista:
Chinese Journal of Epidemiology
Año:
2018
Tipo del documento:
Artículo
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