Effects of glucagon-like peptide 2 on recovery of small intestinal epithelia from radiation injury in mice / 第三军医大学学报
Journal of Third Military Medical University
;
(24): 293-295, 2001.
Artículo
en Chino
| WPRIM
| ID: wpr-736951
ABSTRACT
Objective To investigate the effects of glucagon-like peptide 2 (GLP-2) on recovery of small intestinal epithelia from radiation injury in mice. Methods Mice received a single 8 Gy dose of total body irradiation from 60Co gamma ray followed by treatment with GLP-2 or vehicle. DNA and protein content in small intestinal mucosa were measured, and small intestine was processed for histological examination with light microscope and scanning electron microscope. Results Small intestinal mucosal DNA and protein content, villus height, and villus number significantly decreased in irradiated mice, partial villus tips were ulcerated. GLP-2 administration caused increase in DNA and protein content, villus height, and villus number as compared with irradiated control group. Meanwhile, the villus tips were lack of ulceration. Conclusion GLP-2 can promote recovery of small intestinal epithelia from radiation injury in mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Journal of Third Military Medical University
Año:
2001
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS