Genomic diversity and population structure of Helicobacter pylori isolates in China / 中华流行病学杂志

ABSTRACT

Objective To learn about the overall genomic characteristics and population structure of Helicobacterpylori isolated in China.Methods In this study,we used 10 public available genome sequences of H.pylori strains isolated in China,combined with other H.pylori sequences from GenBank,to analyzed the overall genomic characteristics of H.pylori isolated in China.Core genes and strain specific genes were determined for a further function definition.Results A total of 1 203 core genes were found among all sequenced China H.pylori isolates.The number of strain specific genes ranged from 19 to 32.These genes mainly encodes hypothetical proteins which might play an important role in adaption to different hosts.Genomic variation regions were mainly in genes encoding type four secretion systems and restriction modification systems.All the China isolates belong to hpEastAsia group,hspEAsia subgroup.Prophages sequences were found in three China H.pylori strains,carrying key elements required for phage assembly.Conclusion China H.pylori isolates belong to hpEastAsia group,hspEAsia subgroup,and some isolates contain prophages.