The Effect of Intracameral Triamcinolone Acetonide Injection on the Cornea in Rabbits
Journal of the Korean Ophthalmological Society
;
: 634-640, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-73793
ABSTRACT
PURPOSE:
To evaluate the safety and effects of intracameral triamcinolone acetonide injection in rabbit corneas.METHODS:
Triamcinolone acetonide in the amounts of 0.5, 1, and 2 mg was injected into the anterior chamber of rabbit eyes, and intraocular pressure, corneal thickness, and endothelial cell counts were evaluated on days 1, 3, 7, 14, and 28. Twenty-eight days after triamcinolone acetonide injection, the eyes were enucleated and examined after TUNEL staining.RESULTS:
No statistically significant differences were found among control, 0.5, and 1 mg triamcinolone-injected eyes in central corneal thickness, endothelial cell density, pleomorphism, and polymegathism. There was no difference between 2 mg triamcinolone-injected eyes and control eyes for corneal thickness and cell density, but there were statistically significant differences between these two groups for pleomorphism (p<0.05) and polymegathism (p<0.05).CONCLUSIONS:
The results of this study suggested that intracameral injections of 0.5~1 mg of triamcinolone acetonide are beneficial and cause no toxic effects on corneas.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Triamcinolona
/
Triamcinolona Acetonida
/
Recuento de Células
/
Córnea
/
Etiquetado Corte-Fin in Situ
/
Células Endoteliales
/
Ojo
/
Presión Intraocular
/
Cámara Anterior
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Año:
2008
Tipo del documento:
Artículo
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