Oncogene-Driven Metabolic Alterations in Cancer
Biomolecules & Therapeutics
;
: 45-56, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-739646
ABSTRACT
Cancer is the leading cause of human deaths worldwide. Understanding the biology underlying the evolution of cancer is important for reducing the economic and social burden of cancer. In addition to genetic aberrations, recent studies demonstrate metabolic rewiring, such as aerobic glycolysis, glutamine dependency, accumulation of intermediates of glycolysis, and upregulation of lipid and amino acid synthesis, in several types of cancer to support their high demands on nutrients for building blocks and energy production. Moreover, oncogenic mutations are known to be associated with metabolic reprogramming in cancer, and these overall changes collectively influence tumor-microenvironment interactions and cancer progression. Accordingly, several agents targeting metabolic alterations in cancer have been extensively evaluated in preclinical and clinical settings. Additionally, metabolic reprogramming is considered a novel target to control cancers harboring un-targetable oncogenic alterations such as KRAS. Focusing on lung cancer, here, we highlight recent findings regarding metabolic rewiring in cancer, its association with oncogenic alterations, and therapeutic strategies to control deregulated metabolism in cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biología
/
Regulación hacia Arriba
/
Carcinoma de Pulmón de Células no Pequeñas
/
Glutamina
/
Glucólisis
/
Neoplasias Pulmonares
/
Metabolismo
Límite:
Humanos
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2018
Tipo del documento:
Artículo
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