Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer
Genomics & Informatics
;
: e35-2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-739678
ABSTRACT
Biliary tract cancer (BTC) is a rare cancer and is associated with a poor prognosis. To understand the genetic characteristics of BTC, we analyzed whole-exome sequencing data and identified somatic mutations in patients with BTC. Tumors and matched blood or normal samples were obtained from seven patients with cholangiocarcinoma who underwent surgical resection. We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. Activating mutations of KRAS and NRAS were also identified. Our analyses identified somatic mutations in Korean patients with BTC
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Sistema Biliar
/
Neoplasias del Sistema Biliar
/
Genes Supresores de Tumor
/
Colangiocarcinoma
/
Exoma
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Genomics & Informatics
Año:
2018
Tipo del documento:
Artículo
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