Suspected Perinatal Depression Revealed to be Hereditary Diffuse Leukoencephalopathy with Spheroids
Journal of Movement Disorders
; : 59-61, 2017.
Article
en En
| WPRIM
| ID: wpr-73978
Biblioteca responsable:
WPRO
ABSTRACT
Early motor symptoms of neurodegenerative diseases often appear in combination with psychiatric symptoms, such as depression or personality changes, and are in danger of being misdiagnosed as psychogenic in young patients. We present the case of a 32-year-old woman who presented with rapid-onset depression, followed by a hypokinetic movement disorder and cognitive decline during pregnancy. Genetic testing revealed a mutation in the colony-stimulating factor 1 receptor gene, which led to the diagnosis of hereditary diffuse leukoencephalopathy with spheroids. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is probably an under-recognized disease. HDLS should be considered in patients with rapidly progressing parkinsonian symptoms and dementia accompanied by white matter lesions.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Pruebas Genéticas
/
Factor Estimulante de Colonias de Macrófagos
/
Enfermedades Neurodegenerativas
/
Trastornos Parkinsonianos
/
Demencia
/
Depresión
/
Diagnóstico
/
Leucoencefalopatías
/
Sustancia Blanca
/
Trastornos del Movimiento
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Journal of Movement Disorders
Año:
2017
Tipo del documento:
Article