Clinical Features Indicating Nigrostriatal Dopaminergic Degeneration in Drug-Induced Parkinsonism
Journal of Movement Disorders
;
: 35-39, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-73982
ABSTRACT
OBJECTIVE:
Patients with drug-induced parkinsonism (DIP) may have nigrostriatal dopaminergic degeneration. We studied the clinical features that may indicate nigrostriatal dopaminergic degeneration in patients with DIP.METHODS:
Forty-one DIP patients were classified into normal and abnormal [¹⁸F] FP-CIT scan groups. Differences in 32 clinical features and drug withdrawal effects were studied.RESULTS:
Twenty-eight patients had normal (Group I) and 13 patients had abnormal (Group II) scans. Eight patients of Group I, but none of Group II, had taken calcium channel blockers (p = 0.040). Three patients of Group I and six of Group II had hyposmia (p = 0.018). After drug withdrawal, Group I showed greater improvement in Unified Parkinson's Disease Rating Scale total motor scores and subscores for bradykinesia and tremors than Group II. Only hyposmia was an independent factor associated with abnormal scans, but it had suboptimal sensitivity.CONCLUSION:
None of the clinical features were practical indicators of nigrostriatal dopaminergic degeneration in patients with DIP.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Temblor
/
Bloqueadores de los Canales de Calcio
/
Hipocinesia
/
Trastornos Parkinsonianos
/
Tomografía de Emisión de Positrones
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Movement Disorders
Año:
2017
Tipo del documento:
Artículo
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