Your browser doesn't support javascript.
loading
Immunotherapy in endometrial cancer: new scenarios on the horizon / 부인종양
Journal of Gynecologic Oncology ; : e46-2019.
Artículo en Inglés | WPRIM | ID: wpr-740193
ABSTRACT
This extensive review summarizes clinical evidence on immunotherapy and targeted therapy currently available for endometrial cancer (EC) and reports the results of the clinical trials and ongoing studies. The research was carried out collecting preclinical and clinical findings using keywords such as immune environment, tumor infiltrating lymphocytes, programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) expression, immune checkpoint inhibitors, anti-PD-1/PD-L1 antibodies and others' on PubMed. Finally, we looked for the ongoing immunotherapy trials on ClinicalTrials.gov. EC is the fourth most common malignancy in women in developed countries. Despite medical and surgical treatments, survival has not improved in the last decade and death rates have increased for uterine cancer in women. Therefore, identification of clinically significant prognostic risk factors and formulation of new rational therapeutic regimens have great significance for enhancing the survival rate and improving the outcome in patients with advanced or metastatic disease. The identification of genetic alterations, including somatic mutations and microsatellite instability, and the definition of intracellular signaling pathways alterations that have a major role in in tumorigenesis is leading to the development of new therapeutic options for immunotherapy and targeted therapy.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Uterinas / Terapia Biológica / Países Desarrollados / Tasa de Supervivencia / Factores de Riesgo / Mortalidad / Linfocitos Infiltrantes de Tumor / Neoplasias Endometriales / Inestabilidad de Microsatélites / Terapia Molecular Dirigida Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Gynecologic Oncology Año: 2019 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Uterinas / Terapia Biológica / Países Desarrollados / Tasa de Supervivencia / Factores de Riesgo / Mortalidad / Linfocitos Infiltrantes de Tumor / Neoplasias Endometriales / Inestabilidad de Microsatélites / Terapia Molecular Dirigida Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos Idioma: Inglés Revista: Journal of Gynecologic Oncology Año: 2019 Tipo del documento: Artículo