Regulation of Allergic Immune Responses by Microbial Metabolites
Immune Network
;
: e15-2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-740197
ABSTRACT
Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are recognized by the host through the epithelium, acting as a physical barrier. Two allergic diseases, atopic dermatitis and food allergy, are closely linked to the microbiota, because inflammatory responses occur on the epidermal border. The microbiota generates metabolites such as short-chain fatty acids and poly-γ-glutamic acid (γPGA), which can modulate host immune responses. Here, we review how microbial metabolites can regulate allergic immune responses. Furthermore, we focus on the effect of γPGA on allergic T helper (Th) 2 responses and its therapeutic application.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Accesibilidad Arquitectónica
/
Dermatitis Atópica
/
Epitelio
/
Células T Asesinas Naturales
/
Ácidos Grasos Volátiles
/
Microbiota
/
Hipersensibilidad a los Alimentos
Idioma:
Inglés
Revista:
Immune Network
Año:
2018
Tipo del documento:
Artículo
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