Your browser doesn't support javascript.
loading
Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson's Disease and in Neurologically Intact Subjects
Journal of Neurogastroenterology and Motility ; : 469-478, 2018.
Artículo en Inglés | WPRIM | ID: wpr-740747
ABSTRACT
BACKGROUND/

AIMS:

α-Synucleinopathy in the brain is the neuropathological hallmark of Parkinson’s disease (PD). However, the functional impact of α-synucleinopathy in the enteric nervous system remains unknown. We aim to evaluate the association between gastrointestinal (GI) dysfunction and α-synuclein (αSYN) pathology in the stomach and colon of PD patients and controls, as well as to investigate the association between the αSYN pathology in GI tract and future PD risk.

METHODS:

A total of 35 PD patients and 52 neurologically intact subjects were enrolled in this study. Endoscopic biopsies were performed, and then immunohistochemical staining for αSYN was performed. All subjects completed the validated Rome III questionnaire for the assessment of GI symptoms. The association between GI symptoms and the αSYN pathology in GI mucosa was evaluated. Incident PD cases were assessed during a median follow-up of 46 months.

RESULTS:

The proportion of self-reported constipation and functional constipation through the Rome III questionnaire was significantly higher in PD patients than in controls (P 0.05). No incident PD cases were diagnosed during study period.

CONCLUSIONS:

Our present study suggests that the deposition of αSYN in the mucosal enteric nervous system may not be reflected by functional impairment of the affected segment of the gut.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Patología / Estómago / Biopsia / Encéfalo / Estudios de Seguimiento / Colon / Sistema Nervioso Entérico / Estreñimiento / Tracto Gastrointestinal Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Journal of Neurogastroenterology and Motility Año: 2018 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Enfermedad de Parkinson / Patología / Estómago / Biopsia / Encéfalo / Estudios de Seguimiento / Colon / Sistema Nervioso Entérico / Estreñimiento / Tracto Gastrointestinal Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Journal of Neurogastroenterology and Motility Año: 2018 Tipo del documento: Artículo