Studies on the Interactions of M1-, M2- Receptors with Nicotinic Receptors in Rabbit Sympathetic Ganglia
Journal of Korean Neurosurgical Society
;
: 1234-1243, 1994.
Artículo
en Inglés
| WPRIM
| ID: wpr-74075
ABSTRACT
Effects of a M1 receptor antagonist, pirenzepine, a M2 receptor antagonist, AF-DX116, and a nicotinic receptor antagonist, mecamylamine on the pressor responses to preganglionic sympathetic nerve stimulation(PNS) and McN-A-343 and DMPP in spinal(pithed) rabbits were investigated in order to elucidate a functional role of M1, M2 and nicotinic receptors in ganglionic transmission. Pirenzepine and AF-DX116 selectively inhibited the McN-A-343-induced pressor reponse in chlorisondamine-treated rabbit and the BCh-induced bradycardia, respectively. Electrical stimulations of preganglionic sympathetic outflow at T8 level produced increases in blood pressure. Pirenzepine(3 microgram/kg) significantly inhibited the PNS-induced pressor response and the degree of inhibition was not changed by increasing the doses to 100 microgram/kg. AF-DX116(100 microgram/kg) had no effect on the PNS-induced pressor response. Mecamylamine inhibited the PNS-induced pressor response in a dose-dependent manner. The inhibitory action of mecamylamine was significantly augmented by combined-treatment with pirenzepine(30 microgram/kg) but AF-DX116(100 microgram/kg) did not affect the inhibitory action of mecamylamine. McN-A-343 and DMPP elicited pressor response in the spinal rabbit. Pirenzepine and AF-DX116 dose-dependently inhibited the McN-A-343-induced pressor response but they did not affect DMPP-induced pressor response. Mecamylamine inhibited both pressor responses induced by Mc-N-343- and DMPP. These results suggest that not only nicotinic receptors but also M1 receptors play a facilitatory role in ganglionic transmission but M2 receptors do not contribute the transmission in spinal(pithed) rabbits.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
Pirenzepina
/
Bradicardia
/
Receptores Nicotínicos
/
Ganglión
/
Yoduro de Dimetilfenilpiperazina
/
Estimulación Eléctrica
/
Ganglios Simpáticos
/
Cloruro de (4-(m-Clorofenilcarbamoiloxi)-2-butinil)trimetilamonio
/
Mecamilamina
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Korean Neurosurgical Society
Año:
1994
Tipo del documento:
Artículo
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