Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder
Journal of Pathology and Translational Medicine
;
: 121-125, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-741159
ABSTRACT
Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Colecistectomía
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Estudios de Seguimiento
/
Quimioterapia Adyuvante
/
Carcinoma Neuroendocrino
/
Carcinoma Adenoescamoso
/
Quimioterapia
/
Vesícula Biliar
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Pathology and Translational Medicine
Año:
2018
Tipo del documento:
Artículo
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