The Role of MicroRNAs in Oncogenesis and Progression of Prostate Cancer
Korean Journal of Urological Oncology
; : 1-6, 2018.
Article
en Ko
| WPRIM
| ID: wpr-741470
Biblioteca responsable:
WPRO
ABSTRACT
MicroRNAs (miRNAs) are small noncoding RNAs that target mRNA to reduce gene and protein expression by repressing their targets' translation or inducing mRNA degradation. They play fundamental roles in various cancers, including prostate cancer. Each single miRNA may regulate hundreds of genes, and a certain gene may serve as a target by multiple miRNAs. Hence, miRNAs modulate, cell cycle, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis, etc. In this review, we will summarize the several miRNAs that may function as oncogenes and tumor suppressors. And we will describe the each miRNAs associated with cell cycle, apoptosis, EMT, and metastasis in prostate cancer.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Oncogenes
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Próstata
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Neoplasias de la Próstata
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ARN Mensajero
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Ciclo Celular
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Apoptosis
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Estabilidad del ARN
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MicroARNs
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ARN Pequeño no Traducido
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Transición Epitelial-Mesenquimal
Idioma:
Ko
Revista:
Korean Journal of Urological Oncology
Año:
2018
Tipo del documento:
Article