Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 11-2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-741583
ABSTRACT
BACKGROUND:
Botulinum toxin injection on the masticatory muscle induces the osteopenic condition on the ipsilateral condyle. Bisphosphonate suppresses bone resorption and is used to treat osteopenic or osteoporotic condition. This study aimed to evaluate the effect of bisphosphonate administration on prevention of condylar resorption and botulinum toxin A-induced disuse osteopenia in rats.RESULTS:
The volume of the condyle and bone volume/tissue volume (BV/TV, %) showed a strong tendency towards statistical significance (p = 0.052 and 0.058). Trabecular thickness (Tb.Th, mm) and trabecular number (Tb.N, 1/mm) were significantly smaller in the Botox group than in the other groups (p < 0.05). The volume of the condyle and BV/TV in the bisphosphonate 100 and bisphosphonate 200 groups showed similar values when compared with the control group.CONCLUSION:
Bisphosphonate administration after botulinum toxin A injection in the masticatory muscles appears to prevent condyle resorption and botulinum toxin-induced disuse osteopenia in rats.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Articulación Temporomandibular
/
Enfermedades Óseas Metabólicas
/
Resorción Ósea
/
Toxinas Botulínicas
/
Cóndilo Mandibular
/
Músculos Masticadores
Límite:
Animales
Idioma:
Inglés
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Año:
2019
Tipo del documento:
Artículo
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