Adrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats
Yonsei Medical Journal
; : 252-257, 2000.
Article
en En
| WPRIM
| ID: wpr-74161
Biblioteca responsable:
WPRO
ABSTRACT
We investigated the adrenergic sensitivity of afferent fibers in the L4 dorsal roots of rats with a unilateral ligation of the L5-L6 spinal nerves. About 12% of nociceptive fibers on the affected side were excited by sympathetic stimulation or by intra-arterial injection of norepinephrine which did not affect A beta-fiber activity. Sympathetic excitation of nociceptive fibers was suppressed by alpha 1-antagonist prazosin, while it was unaffected by alpha 2-antagonist yohimbine. Most of these fibers were excited by intra-arterial injection of alpha 1-agonist phenylephrine, without being affected by an injection of alpha 2-agonist clonidine. Sympathetic excitation was blocked by lidocaine applied near the receptive fields of recorded fibers. The results suggested that some nociceptors remaining intact after partial nerve injury become sensitive to sympathetic activity by the mediation of alpha 1-adrenoceptors in the peripheral endings.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Dolor
/
Nociceptores
/
Norepinefrina
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Ratas Sprague-Dawley
/
Receptores Adrenérgicos alfa 1
/
Animales
/
Fibras Nerviosas
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2000
Tipo del documento:
Article