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Anti-nociceptive and Anti-inflammatory Properties of Ilex latifolia and its Active Component, 3,5-Di-caffeoyl Quinic Acid Methyl Ester
Natural Product Sciences ; : 64-71, 2019.
Artículo en Inglés | WPRIM | ID: wpr-741642
ABSTRACT
The present study was conducted to investigate anti-nociceptive and anti-inflammatory effects of the leaves of Ilex latifolia Thunb (I. latifolia) in in vivo and in vitro. Writhing responses induced by acetic acid and formalin- and thermal stimuli (tail flick and hot plate tests)-induced pain responses for nociception were evaluated in mice. I. latifolia (50 – 200 mg/kg, p.o.) and ibuprofen (100 mg/kg, p.o.), a positive non-steroidal anti-inflammatory drug (NSAID), inhibited the acetic acid-induced writhing response and the second phase response (peripheral inflammatory response) in the formalin test, but did not protect against thermal nociception and the first phase response (central response) in the formalin test. These results show that I. latifolia has a significant anti-nociceptive effect that appears to be peripheral, but not central. Additionally, I. latifolia (50 and 100 µg/mL) and 3,5-di-caffeoyl quinic acid methyl ester (5 µM) isolated from I. latifolia as an active compound significantly inhibited LPS-induced NO production and mRNA expression of the pro-inflammatory mediators, iNOS and COX-2, and the pro-inflammatory cytokines, IL-6 and IL-1β, in RAW 264.7 macrophages. These results suggest that I. latifolia can produce antinociceptive effects peripherally, but not centrally, via anti-inflammatory activity and supports a possible use of I. latifolia to treat pain and inflammation.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ácido Quínico / Técnicas In Vitro / Dimensión del Dolor / ARN Mensajero / Ibuprofeno / Citocinas / Interleucina-6 / Ácido Acético / Ilex / Ciclooxigenasa 2 Límite: Animales Idioma: Inglés Revista: Natural Product Sciences Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Ácido Quínico / Técnicas In Vitro / Dimensión del Dolor / ARN Mensajero / Ibuprofeno / Citocinas / Interleucina-6 / Ácido Acético / Ilex / Ciclooxigenasa 2 Límite: Animales Idioma: Inglés Revista: Natural Product Sciences Año: 2019 Tipo del documento: Artículo