Your browser doesn't support javascript.
loading
Initial clinical outcomes of proton beam radiotherapy for hepatocellular carcinoma
Radiation Oncology Journal ; : 25-34, 2018.
Artículo en Inglés | WPRIM | ID: wpr-741931
ABSTRACT

PURPOSE:

This study aimed to evaluate the initial outcomes of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) in terms of tumor response and safety. MATERIALS AND

METHODS:

HCC patients who were not indicated for standard curative local modalities and who were treated with PBT at Samsung Medical Center from January 2016 to February 2017 were enrolled. Toxicity was scored using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. Tumor response was evaluated using modified Response Evaluation Criteria in Solid Tumors (mRECIST).

RESULTS:

A total of 101 HCC patients treated with PBT were included. Patients were treated with an equivalent dose of 62–92 GyE10. Liver function status was not significantly affected after PBT. Greater than 80% of patients had Child-Pugh class A and albumin-bilirubin (ALBI) grade 1 up to 3-months after PBT. Of 78 patients followed for three months after PBT, infield complete and partial responses were achieved in 54 (69.2%) and 14 (17.9%) patients, respectively.

CONCLUSION:

PBT treatment of HCC patients showed a favorable infield complete response rate of 69.2% with acceptable acute toxicity. An additional follow-up study of these patients will be conducted.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Protones / Radioterapia / Estudios de Seguimiento / Carcinoma Hepatocelular / Terapia de Protones / Criterios de Evaluación de Respuesta en Tumores Sólidos / Hígado Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2018 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Protones / Radioterapia / Estudios de Seguimiento / Carcinoma Hepatocelular / Terapia de Protones / Criterios de Evaluación de Respuesta en Tumores Sólidos / Hígado Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2018 Tipo del documento: Artículo