Eradication Rates of 10-day Sequential Therapy for Helicobacter pylori: Results of an 8-year Prospective Study Conducted at a Tertiary Korean Hospital / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 99-104, 2019.
Artículo
en Coreano
| WPRIM
| ID: wpr-742135
ABSTRACT
BACKGROUND/AIMS:
The Helicobacter pylori (H. pylori) eradication rate of standard triple therapy is unsatisfactory in Korea, and sequential therapy (SQT) has been suggested to be a practical first-line alternative regimen. The aim of this prospective study was to document changes in annual eradication rates of SQT.METHODS:
A total of 983 H. pylori-positive subjects were enrolled from 2010 to 2018 and their data were subjected to intention-to-treat (ITT) and per-protocol (PP) analysis. All subjects received 10-day sequential therapy consisting of 40 mg esomeprazole and 1 g amoxicillin b.i.d for 5 days followed by 40 mg esomeprazole b.i.d, 500 mg clarithromycin b.i.d and 500 mg metronidazole t.i.d for 5 days. The 13C-urea breath test, rapid urease test (CLO test®), and histology were used to confirm eradication. Compliance and side effects were also investigated.RESULTS:
ITT and PP eradication rates of SQT were 69.9% (687 of 983) and 87.1% (657 of 754), respectively. The annual eradication rate of ITT remained consistent over the 8-year study period (p for trend=0.167), whereas PP analysis showed the eradication rate increased (p for trend=0.042). The overall adverse event rate for SQT was 41.7% (410 subjects).CONCLUSIONS:
Despite high antibiotic resistance rates in Korea, the eradication rate of SQT did not decrease over the 8-year study period.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ureasa
/
Pruebas Respiratorias
/
Farmacorresistencia Microbiana
/
Estudios Prospectivos
/
Helicobacter pylori
/
Helicobacter
/
Claritromicina
/
Adaptabilidad
/
Análisis de Intención de Tratar
/
Esomeprazol
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio observacional
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Año:
2019
Tipo del documento:
Artículo
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