Relationship between serum uric acid and arterial calcification in maintenance hemodialysis patients / 国际检验医学杂志

ABSTRACT

Objective To investigate the correlation between serum uric acid and arterial calcification in maintenance hemodialysis patients.Methods 117 patients with maintenance hemodialysis were selected in our hospital.The blood uric acid and related clinical indexes were detected and the coronary artery calcification score (CACs) was measured by multislice spiral CT.The correlation between clinical indicators and coronary artery calcification score in hyperuricemia group and normal group was analyzed.Results The 117 patients with maintenance hemodialysis, 68 patients had elevated serum uric acid, and the incidence of hyperuricemia was 58.12％.The levels of DBP, SBP, TG, TC, hs-CRP and CACs in the hyperuricemia group were significantly higher than those in the normal group (P＜0.05).By correlation analysis, serum uric acid levels were positively correlated with TG, hs-CRP and CACs in patients (P＜0.05).The risk factors for severe vascular calcification (CACs＞400) in patients with persistent hemodialysis include hs-CRP levels, serum uric acid levels, and hypertension.Conclusion The incidence of hyperuricemia is high in continuous hemodialysis patients.There is a close relationship between serum uric acid level and coronary artery calcification.And the level of high blood uric acid is an important factor causing coronary artery calcification in patients.Therefore, the prevention of cardiovascular and cerebrovascular complications in maintenance hemodialysis patients should be paid more attention to the treatment of hyperuricemia.