Diagnostic value of combined detection of MT1-MMP, LncRNA SNHG15 and YAP in thyroid carcinoma / 国际检验医学杂志

ABSTRACT

Objective To explore the diagnostic value of combined detection of MT1-MMP, LncRNA SNHG15and YAP in thyroid carcinoma.Methods A total of 186thyroid carcinoma patients from July 2015to July 2017were selected as the observation group and 50healthy patients were selected as control group.The expression levels of MT1-MMP, LncRNA SNHG15, and YAP in tissues of the two groups were compared.The relationships between the clinical pathological parameters of thyroid carcinoma and the expression levels of MT1-MMP, LncRNA SNHG15, YAP were analyzed.Results The positive rate of MT1-MMP, YAP and LncRNA SNHG15in observation group were significantly higher than those in control group (P<0.05) .The expression level of YAP in tumors larger than 2cm diameter was significantly higher than that in tumors less than 2cm (P<0.05) .The expression level of YAP and LncRNA SNHG15with envelope infiltration were significantly higher than those without envelope infiltration (P<0.05) .The expression level of MT1-MMP in lymph node metastasis group was significantly higher than that in non-lymphatic metastasis group (P<0.05) .The expression level of YAP in gradesⅢandⅣof TNM were significantly higher than those in gradesⅠandⅡ (P<0.05) .Conclusion High expression level of MT1-MMP is associated with infiltration of thyroid carcinoma capsules and lymphatic metastasis.YAP is associated with greater proliferative capacity of papillary thyroid carcinoma, and LncRNA SNHG15is closely associated with infiltration of capsules.