Osteoprotegerin gene polymorphism is not associated with the risk of large atherosclerotic stroke in Han population in Liaoning, China / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlation between the gene polymorphism of osteoprotegerin genes rs3134069,rs2073617 and rs2073618 and the onset risk of large artery atherosclerotic stroke (LAA) in the Han population in Liaoning,China.Methods Using the case-control study design,213 patients with LAA were selected as case group according to the TOAST etiology classification,and 197 health subjects in the same period were selected as control group.Rs3134069,rs2073617,and rs2073618 were genotyped using the modified multiplex ligase reaction technique.Multivariate logistic regression analysis was used to determine the independent correlation between gene polymorphism and LAA.Results There were no significant differences in the genotypes and alsle distribution frequencies of OPG genes rs3134069,rs2073617 and rs2073618 between the case group and the control group (all P ＞0.05).The dominant and recessive models also showed that there were no significant differences (all P＞0.05).Conclusion The polymorphisms of OPG genes rs3134069,rs2073617 and rs2073618 were not significantly associated with LAA susceptibility in Han population of Liaoning,China.The presence of each allele could not constitute a risk factor for the onset of LAA.