Roles of exosomes in tumor formation, diagnosis and treatment / 国际肿瘤学杂志

ABSTRACT

Exosomes are subcellular membrane structures secreted by both normal cells and tumor cells.They contain a variety of specific microRNAs (miRNAs) and signaling molecules,and have important research value in tumorigenesis,tumor diagnostic classification and immunotherapy.The effect of exosomes on tumorigenesis is a double-edged sword,and the miRNAs act as molecular markers and contribute to classify morphologically intractable tumors such as glioblastoma.In antineoplastic therapy,exosomes can be used as drug carriers or induce a new type of immunotherapy through their own characteristics.