Effect of non-thyroidal illness syndrome on thyroid function and its prognosis in children / 中华实用儿科临床杂志

ABSTRACT

Some systemic diseases also can cause changes in thyroid hormone levels in the human body,called the non-thyroidal illness syndrome (NTIS),which occur in both children and adults.NTIS is more common in neonates,surgical patients,patients at intensive care unit and patients with genetic disease patients.Deiodinase activity,hypothalamic-pituitary-thyroid axis,thyroid hormone transporters,serum binding proteins,nuclear thyroid hormone receptors,cytokines,and oxidative stress are factors for developing NTIS.The prognosis of NTIS is often adaptive and self-limiting.The treatment of thyroid hormone supplementation during the disease needs further study.