Analysis of characteristics and related factors of secretory otitis media after radiotherapy for nasopharyngeal carcinoma / 中国基层医药

ABSTRACT

Objective To observe the characteristics of secretory otitis media after radiotherapy for nasopha-ryngeal carcinoma(NPC) and analyze its related factors.Methods From January 2015 to January 2017,one hundred and eighty-four NPC patients with secretory otitis media after radiotherapy in the Fifth People＇s Hospital of Datong were selected as observation group,and 56 NPC patients without secretory otitis media were selected as control group.The time and location of secretory otitis media after radiotherapy for NPC patients were observed and recorded.The clinical data of the two groups were compared,and the related factors were analyzed.Results Of the 184 patients,67.4% patients were unilateral and 32.6% patients were double ears.Twelve months after radiotherapy,the highest incidence rate was 44.6% (82/184).Compared with the control group,the radiotherapy time of the observation group[(13.6 ± 4.8)months] was longer,the radiation dose[(72.7 ± 26.8) Gy] was greater,the proportion of the eustachian tube involvement(65.2% ),the T3-T4 phase of the tumor stage(55.4% ) and the atrophy of the palatine tensor muscle of the palatine velum more than or equal to 30% (63.0% ) were higher,and the differences were statistically significant (t=6.231,5.683,χ2 =8.944,5.527,7.198,all P<0.05).Logistic multivariate analysis showed that the radiation dose of more than 70Gy, palatine tensor muscle atrophy more than 30% , tumor T3 - T4 staging, eustachian tube involvement and radiotherapy time were the risk factors of secretory otitis media in NPC patients after radiotherapy. Conclusion The postoperative radiotherapy of NPC with secretory otitis media is often in one side.The risk factors are the time of radiotherapy,the dose of radiotherapy,the tumor stage,the involvement of the eustachian tube and the atrophy of the palatine tensor muscle.