The role of regional lymphadenectomy in surgical treatment of nonfunctional pancreatic neuroendocrine tumors / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
;
(12): 49-52, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-745332
ABSTRACT
Objective To analyze the prognostic importance of lymph node metastasis and the significance of regional lymphadenectomy in surgical treatment of nonfunctional pancreatic neuroendocrine tumors(NF-PanNET).Methods The clinical and pathological data of patients who underwent resection of NF-PanNET in Tianjin Medical University Cancer Institute and Hospital from January 2000 to December 2013 were retrospectively studied.The data included age,sex,tumor location,tumor size,lymph node metastasis,surgical resection margins,pathological grades and followed-up visits.Results Of 75 patients in this study,16 (21.3%) had lymph node metastases.Patients with larger tumors (>3 cm) and higher tumor gradings (G3) had higher rates of lymph nodal metastasis.The overall 3-and 5-year disease-free survival (DFS) were 92.0% and 89.2% respectively.The 5-year DFS for patients with and without nodal metastasis were 75.0% and 93.0% (P<0.05) respectively.Significantly lower 5-year DFS rates were found in patients with lymph nodal metastases,large tumor sizes (>3 cm),high pathological gradings (G3) and positive surgical resection margins (all P<0.05).Multivariable analysis showed that lymph nodal metastasis and surgical resection margin were independent factors associated with DFS (all P<0.05).Conclusions Patients with NF-PanNET with lymph node metastasis had significantly higher risks of recurrence and metastasis.Patients with large tumor sizes (>3 cm) had a higher rate of lymph node metastasis,and radical surgery with lymph node dissection is recommended for these patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Hepatobiliary Surgery
Año:
2019
Tipo del documento:
Artículo
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