Progress in serum markers for non-alcoholic fatty liver disease / 中华检验医学杂志

ABSTRACT

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing gradually. The pathological changes of NAFLD can progress from simple hepatic steatosis to steatohepatitis , and to advanced liver fibrosis ultimately. Accurate diagnosis and identification of nonalcoholic steatohepatitis (NASH) and fibrosis patients are necessary for the treatment and management of NAFLD. The traditional gold standard--liver biopsy is an invasive procedure that is not suitable for clinical practice and clinical trials. Some non-invasive markers for NAFLD based on serological testing will be a new direction for the diagnosis of NAFLD. This article reviews the laboratory tests, clinical parameters, genomic and metabolomics-related NAFLD non-invasive serological markers.