Progress of B7-H6 molecule in malignant tumors / 肿瘤研究与临床

ABSTRACT

B7-H6 has been discovered as a new member of the B7 family in recent years, it can specifically bind to the NKp30, an activated receptor of natural killer (NK) cells to mediate NK cells' tumor immunity killing effect. B7-H6 expression is upregulated in a wide variety of malignant tumor cells, but expression deficiency in normal tissue is detected. The intrinsic mechanism of B7-H6 regulation has been explored, and the treatment targeting B7-H6 has achieved a good effect in animal experiments, which shows a wide prospect of clinical application. This paper summarizes the latest progress of B7-H6 molecule in malignant tumors.