Expression of OX40 and Bcl-2 in allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1057-1059, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-746534
ABSTRACT
OBJECTIVE@#To investigate the role of OX40 and Bcl-2 in allergic rhinitis(AR).@*METHOD@#Twenty-three subjects of allergic rhinitis as experimental group were collected and 20 subjects of deflection of nasal septum as control group. OX40 and Bcl-2 expression were examined in biopsy specimens of AR patients and nasal septum patients by immunohistochemistry respectively. The relationship between OX40 and Bcl-2 expression was analyzed.@*RESULT@#OX40 and Bcl-2 expression increased in the AR patients. There were positive staining not only in CD4+ T cells,but also in vascular endothelial cell, epithelial cell and glandular epithelium cell (P < 0.01). Compared with control group, the expression of OX40 (0.239 4 +/- 0.033 5) and Bcl-2 (0.237 3 +/- 0.042 1) were significantly higher than that in control group (P < 0.01). The OX40 expression was closely related to Bcl-2 expression (r = 0.869 0, P < 0.05).@*CONCLUSION@#The abnormal expression of costimulatory molecule OX40 is well evidenced in AR. Bcl-2 expression is likely mediated by OX40 signal pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Biopsia
/
Estudios de Casos y Controles
/
Rinitis Alérgica Perenne
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Receptores OX40
/
Metabolismo
/
Mucosa Nasal
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2008
Tipo del documento:
Artículo
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