A Study on the Complications of Renal Transplant Recipients / 대한이식학회지

ABSTRACT

PURPOSE: The purpose of this study was to analyze the complications in renal transplant recipients and analyze the factors that affect the survival rate of transplant kidney and patients. METHODS: Between March 1985 and April 2000, 380 cases of renal transplantation were performed at Yeungnam University Hospital. The results were analyzed retrospectively. RESULTS: Infectious complications occurred 612 times in 215 cases and non-infectious complications occurred 200 times in 143 cases. The region of infection was in the order of urinary tract infection (461 times) and pulmonary infection (44 times). Non-infectious complications were as follows; hyperglycemia in 44 cases, de novo hypertension in 27 cases out of 35 previously normotensive patients, nephrotoxicity caused by CsA in 15 cases, myelosuppression in 14 cases, avascular necrosis in 10 cases, and malignancy in 9 cases. Surgical complications were as follows; renovascular bleeding in 15 cases, ureteral obstruction in 5 cases, lymphocele in 4 cases, ureteral leak in 3 cases, and intestinal obstruction in 3 cases. Out of total 380 cases of renal transplant, 113 times of acute rejection occurred in 99 cases. CONCLUSION: Infectious complications were most frequent complication. There were significant differences in graft survival for living non-related donor kidney transplantation by immunosuppressive regimen. CsA+PD+MMF group results in highest graft survival in living non-related donor kidney transplantation and was followed by CsA+PD group, CsA+PD+AZA group. But CsA+PD+MMF regimen has been used in recent years and it needs to be studied prospectively.